Endothelial cells in health and disease

Cover of: Endothelial cells in health and disease |

Published by Taylor & Francis in Boca Raton .

Written in English

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  • Endothelins.,
  • Vascular endothelium.,
  • Endothelial Cells.,
  • Endothelium.

Edition Notes

Includes bibliographical references and index.

Book details

Statementedited by William C. Aird.
ContributionsAird, William C.
LC ClassificationsQP552.E54 E49 2005
The Physical Object
Paginationxviii, 486 p. :
Number of Pages486
ID Numbers
Open LibraryOL3435209M
ISBN 100824754247
LC Control Number2005277710

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This book is a masterpiece of scholarship that develops a view of endothelial biology that goes far beyond previous worthy attempts. The chapters are well written and throughly contemporary covering molecular biology, physiology, regional specialization, stem cell biology, and pathogenesis of 5/5(1).

This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic by: 8.

This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic target.

Intense in vivo and in vitro investigations have revealed that the endothelial cell is a key element in a wide variety of normal activities and diseases.

A large number of investigators and laboratories have been attracted to endothelial cell research, thus supporting the expansion of the continuously grow­ ing and diversifying field of. Get this from a library. Endothelial cells in health and disease. [William C Aird;] -- Handbook highlighting new and exciting proteomic and genomic techniques for mapping endothelial cell heterogeneity.

It studies endothelial cell function and includes chapters on genetic. Thus, this forum on "endothelial cells in health and disease" focuses on key molecules and processes intimately involved in endothelial cell function and cover areas from endothelial nitric oxide.

Angiogenesis research has been focused for decades on growth factors and has largely overlooked the role of endothelial cell metabolism. Li et al. overview the breakthroughs in endothelial cell metabolism over the past decade and discusses possible therapeutic implications for stimulating or inhibiting vessel growth by manipulating endothelial cell metabolism.

Endothelial cells (ECs) are single-layered cells that line the inside of blood and lymph vessels and mediate the selective movement of substances and cells between the bloodstream and surrounding cells. From: Disease Pathways, Invon Kupffer identified stellate cells as cells of the connective tissue, but later named them phagocytic special endothelial cells of the liver.

Stellate cells were properly identified by Ito inand characterized by Wake two decades later in as the major storage site of retinoids and vitamin A. Endothelial Cell Metabolism in Health and Disease The metabolism of endothelial cells (ECs) has only recently been recognized as a driving force of angiogenesis.

Metabolic pathways, such as glycolysis, fatty acid oxidation, and glutamine metabolism, have distinct, essential roles during vessel formation.

Endothelial cell biology has developed into a vibrant discipline and has become a critical instrument to study several disease processes on the cellular and molecular level.

It is now widely recognized that dysfunctions of normal endothelial cell homeostasis are involved in some of the most. The vasodilation is mediated by the actions of the endothelium-derived relaxing factors nitric oxide and prostacyclin. In addition, endothelial cells release endothelium-derived hyperpolarizing factor, which regulates potassium-channel opening in vascular smooth muscle.

The chemical nature of this molecule remains to be elucidated. Endothelial cell biology in health and disease. New York: Plenum Press, © (OCoLC) Online version: Endothelial cell biology in health and disease.

New York: Plenum Press, © (OCoLC) Document Type: Book: All Authors / Contributors: N Simionescu; Maya Simionescu. Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease. Moccia F(1). Author information: (1)Laboratory of General Physiology, Department of Biology and Biotechnology "L.

Spallanzani", University of Pavia, Pavia, Italy. @   Sha Wang, Junkun Zhan, Xiao Lin, Yanjiao Wang, Yi Wang, Youshuo Liu, CircRNA‐ from hyperglycaemia‐stimulated vascular endothelial cell exosomes regulates senescence in vascular smooth muscle cells, Cell Biochemistry and Function, /cbf, 38, 8, (), ().

Endothelial cells form adaptable transport networks but have also emerged as critical regulators of organ growth, regeneration and stem cell niche function.

Even within the same organ, endothelial cells can have very different developmental origins, possess heterogeneous molecular properties and acquire functional specialization. Title: Endothelial Chemokines in Autoimmune Disease VOLUME: 10 ISSUE: 2 Author(s):Kent W.

Christopherson II and Robert A. Hromas Affiliation:Cancer Research and Treatment Center, University of New Mexico Health Science Center, Camino de Salud, Albuquerque, NMUSA. Keywords:chemokine, chemokine receptor, autoimmune disease, rheumatoid arthritis, multiple. Given the central role of endothelial function in cardiovascular health, we herein provide a number of considerations that warrant future research and considering a paradigm shift toward identifying the molecular underpinnings of endothelial resilience.

Abstract. Endothelial colony forming cells (ECFCs) represent the only known truly endothelial precursors. ECFCs are released in peripheral circulation to restore the vascular networks dismantled by an ischemic insult or to sustain the early phases of the angiogenic switch in solid tumors.

The endothelial cell (EC) surface in an adult human is composed of approximately 1 to 6 × 10 13 cells, weighs approximately 1 kg, and covers a surface area of approximately 1 to 7 m ECs line vessels in every organ system and regulate the flow of nutrient substances, diverse biologically active molecules, and the blood cells themselves.

Although most vascular endothelial cells (ECs) and smooth muscle cells (SMCs) are mesoderm-derived, the neural crest also provides some of the cells in the great arteries and. Endothelial cells — the cells that line the entire circulatory system — are key to good health.

A whole foods, plant-based diet protects and prevents endothelial cells from being damaged. Foods that damage endothelial cells include: animal protein including dairy products, refined sugar, caffeine, gluten, and oils.

For COVID patients with serious lung disease, targeting endothelial cells -- cells that comprise the blood vessel wall which regulate oxygen exchange between airways and the bloodstream.

In healthy people, endothelial cells help prevent and stop bleeding, inhibit clotting, regulate blood pressure, and prevent inflammation.

Forming a single cell layer that lines blood vessels, they serve as gatekeepers that allow small molecules and even whole cells to pass in and out of the vessels. 2 days ago  Defects in endothelial cells cause deterioration in kidney function and structure. Here, we found that endothelial SIRT3 regulates metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice.

By analyzing, gain-of-function of the SIRT3 gene by overexpression in a fibrotic mouse strain conferred disease resistance against diabetic kidney fibrosis; while its loss-of-function in. Endothelial Cell Metabolism in Health and Disease Katerina 1,2, Rohlenova,1,2,4 Koen Veys,1,2,4 Ines Miranda-Santos,1,2 Katrien De Bock,3 and Peter disease, with emphasis on the changes in metabolism in the tumor endothelium.

Angiogenesis: From Quiescent Cells to a New Vessel Sprout ECs. migration of human endothelial progenitor cells and increases lipid accumulation in Jia et al. Lipids in Health and Disease () cause a high burden of cardiovascular diseases [ 1].

Endothelial dysfunction precedes atherosclerosis and is an independent predictor of cardiovascular events. It is also a reversible disorder. As an early, reversible event in the development of cardiovascular disease (CVD), strategies to maintain and protect the endothelium are.

Answer: It is the typical western diet of processed oils, dairy, and meat which destroys the lifejacket of our blood vessels known as our endothelial cells. This cell layer is a one cell thick lining of all of our blood vessels. Endothelial cells manufacture a magical protective molecule of gas called nitric oxide, which protects our blood vessels.

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain Nat Commun. Sep 4;11(1) doi: /s Endothelium is the inner most cell layer of blood vessels.

Endothelial cells make special barrier that separate blood from extravascular tissues. Intact endothelium regulates vascular tone and permeability and maintains non-inflammatory, anti-thrombotic surface. Through its ability to express pro-coagulants, anticoagulants, vasoconstrictors, vasodilators, cell adhesion molecules, and cytokines.

Endothelial cells drive the formation of new blood vessels in physiological and pathological contexts such as embryonic development, wound healing, cancer and ocular diseases.

Once formed, all vessels of the vasculature system present an endothelial monolayer (the endothelium), lining the luminal wall of the vessels, that regulates gas and nutrient exchange between the circulating blood and. Endothelial cells (EC) constitute a single layer of the lining of blood vessels and play an important role in maintaining cardiovascular homeostasis.

Endothelial dysfunction has been recognized as a primary or secondary cause of many diseases and it manifests itself, among others, by increased lipid content or a change in the lipid composition in the EC.

Therefore, the analysis of cellular. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.

“The endothelial cells get leaky, so instead of being like saran wrap, it turns into a sieve and then it allows fluid from the bloodstream to accumulate in the air spaces,” Harvard’s Libby said.

For COVID patients with serious lung disease, targeting endothelial cells—cells that comprise the blood vessel wall which regulate oxygen exchange between airways and the bloodstream—may be. "The endothelial cells get leaky, so instead of being like Saran Wrap, it turns into a sieve and then it allows fluid from the bloodstream to accumulate in the airspaces," Harvard's Libby says.

Endothelial cells lining the interior surface of blood vessels play a critical role in heart health, the researchers explained. These cells need to be flexible to help manage blood pressure, and if.

This emerging view of the key role of endothelial cells suggests that a number of existing drugs might dampen or even arrest the fatal second phase of the disease, Becker says. First author Wen Luo found that the main function of VEGF and Notch in arterializing endothelial cells is to inhibit Myc, suppressing its ability to promote cell proliferation and metabolism.

The most prevalent causes of cardiovascular disease are atherosclerosis and thrombosis. Atherosclerosis and thrombosis are mediated by the endothelial cells lining the vasculature, which control vascular homeostasis. Failure of the endothelial cells (ECs) to prevent atherosclerosis and thrombosis motivates our interest in studying this cell type.A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the.Endothelial progenitor cell (or EPC) is a term that has been applied to multiple different cell types that play roles in the regeneration of the endothelial lining of blood wth endothelial cells are an EPC subtype committed to endothelial cell formation.

Despite the history and controversy, the EPC in all its forms remains a promising target of regenerative medicine research.

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