Mitochondria and cancer

Cover of: Mitochondria and cancer |

Published by Springer in New York .

Written in English

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  • Cancer -- Genetic aspects,
  • Mitochondria,
  • Mitochondrial pathology,
  • Cell transformation,
  • Mitochondria -- physiology,
  • Neoplasms -- metabolism,
  • Cell Transformation, Neoplastic,
  • Mitochondrial Diseases,
  • Neoplasms -- drug therapy

Edition Notes

Includes bibliographical references and index.

Book details

StatementKeshav K. Singh, Leslie C. Costello, editors.
ContributionsSingh, Keshav K., Costello, Leslie.
LC ClassificationsRC268.4 .M58 2009
The Physical Object
Paginationxii, 289 p., [4] p. of plates :
Number of Pages289
ID Numbers
Open LibraryOL23575033M
ISBN 100387848347
ISBN 109780387848341
LC Control Number2008940646

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The fascinating miniature world of the mitochondria—its precious role in our healthy cells and how mitochondria gone bad can lead to cancer. Part 2 of a 4-article series about Dr. Thomas Seyfried's vitally important book, Cancer as a Metabolic Disease.

Contrary to conventional wisdom, functional mitochondria are essential for the cancer cell. Although mutations in mitochondrial genes are common in cancer cells, they do not inactivate Cited by: Mitochondria are complex organelles that influence cancer initiation, growth, survival, and metastasis, and many facets of mitochondrial biology beyond energy production actively contribute to tumorigenesis.

These include mitochondrial mass, dynamics, cell death regulation, redox homeostasis, metabolic regulation, and by: Once considered the cause of cancer, a tiny organelle known as the “powerhouse of the cell” may soon spawn a new treatment.

InOtto Warburg, recipient of the Nobel Prize for Medicine or Physiology, attributed cancer to damage to the mitochondria, tiny structures within each cell that are involved in energy production, the manufacture of ATP.

This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for Price: $ Know uses his knowledge of mitochondria and the mitochondrial theory of aging to elucidate the role of mitochondria in chronic disease, from cancer, heart disease, metabolic syndrom and diabetes to neurological diseases like Alzheimer's, Parkinson's, Huntington's, ALS, ADHD, anxiety and depression/5(91).

Reading Time: 9 minutes. >> Summary: A new report on mitochondria and cancer shows how our mitochondria help our cancers to grow. With its 37 genes, mitochondria are an attractive druggable target and researchers are looking at this angle to develop powerful cancer cures.

Here, we review the cancer cell-intrinsic and cell-extrinsic mechanisms through which mitochondria influence all steps of oncogenesis, with a focus on the therapeutic potential of Mitochondria and cancer book Cited by: Cancer cells are normal cells, which start to function differently due to toxic exposure, lack of nutrition, lack of oxygen and exposure to chemicals produced in the body when it is under stress.

The mitochondria malfunction and the cells revert to producing energy by fermentation rather than by processing oxygen. Keywords: Mitochondria, cancer, metabolism, apoptosis, reactive oxygen species. Mitochondria are often described as the “powerhouse” of the cell. While their role in ATP production is critical, mitochondria house numerous other biochemical reactions and lie at the intersection of multiple physiological processes including catabolic and Cited by: This book, Mitochondria and Cancer, edited by Keshav K.

Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for.

The Role of Mitochondria in Cancer and Other Chronic Diseases ROS Damage As stated above, a two-edged sword re-garding ATP production is the simultane-ous production of necessary ROS that may have a role in gene regulation and excessive damaging ROS leading to the disease state, under both aerobic and anaerobic Size: KB.

This book highlights the importance of phytochemicals and mitochondria in cancer Mitochondria and cancer book and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer : Springer New York.

The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nuclear cell mate.

Application of this holistic approach, to all metabolic interactions within the Cited by:   The most vulnerable part of our cells is what’s called mitochondria.

The relationship between the mitochondria and cancer is a delicate one. Mitochondria are the little organelles inside of a cell that take glucose and oxygen, and very efficiently produce a lot of ATP. ATP is the energy currency in biological systems.

Targeting a pathway that controls the movement of mitochondria, the powerhouses of all cells, could reduce cancer invasiveness and resistance to radiotherapy, according to new research. The mechanism by which oocytes harboring the more defective mitochondria are recognized is unknown.

However, one possibility is that the defective mitochondria generate more ROS and this leads to preferential cell death, perhaps through activation of the mtPTP (F an et al. ; S tewart et al. ).Cited by: Targeting mitochondria for cancer therapy Article Literature Review (PDF Available) in Nature Reviews Drug Discovery 9(6) June with 4, Reads How we measure 'reads'.

Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases.

The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution. The book discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis and treatment of mitochondrial diseases.

Three all-inclusive sections examine the role of mitochondria in common medical conditions, such as diabetes, heart failure and the full range of inherited mitochondrial diseases.

"This volume inspires. It certainly will be much appreciated by cell biologists all over the world." Quarterly Review of Biology, March This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as.

Instead, mitochondrial functions in cancer vary depending upon genetic, environmental, and tissue-of-origin differences between tumors. It is clear that the biology of mitochondria in cancer is central to our understanding of cancer biology, as many classical cancer hallmarks result in Cited by: Selective drug delivery to mitochondria helps to increase specificity and reduce toxicity of these agents.

In order to reduce mitochondrial ROS production, mitochondria‐targeted antioxidants can specifically accumulate in mitochondria by affiliating to a lipophilic penetrating cation and prevent mitochondria from oxidative by:   Core tip: This review is devoted to the analysis of mitochondrial function as a therapeutic target to induce cell death in cancer stem cells (CSCs).

In particular, we focused on the differences in energy metabolism and features between CSC and non-CSC mitochondria, and between CSCs and normal stem by: Cancer mitochondria can utilize different kinds of resources, such as glucose, glutamine, and fatty acids, to fuel the electron transport chain (ETC) for OXPHOS.

Moreover, the involvement of mitochondria in cell death mechanisms makes them important targets for tumor therapy. Benny Abraham Kaipparettu Guest Editor. Manuscript Submission.

Mitochondria and Cancer Pdf An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer.

This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer : Springer New York.

Targeting Mitochondria Scientific Committee invites scientists, academics and industrials to present all innovations and researches related to Mitochondria. Please submit your abstract by October 2, To register for Targeting Mitochondriaplease follow this link.

Read more. Mitochondria, cell death and cancer. In normal cells, BAX and to a lesser extent BAK are dynamically shuttled to and from the mitochondria. Following apoptotic stress, BH 3‐only proteins are activated, leading to BAX and BAK activation and mitochondrial Cited by:   The Best Thing About the Ketogenic Diet Keto is most commonly thought to be a weight loss diet for the obese or diabetic.

The reason for that is because when you’re in ketosis, you’re using your own body fat and ketones as a source of fuel instead of glucose. Because certain diseases, such as cancer, involve a breakdown in normal apoptosis, mitochondria are thought to play a role in the disease.

Storing calcium Calcium is vital for a number of cellular. Cancer cells divide uncontrollably due to their metabolic imbalance, resistance to mitochondria-mediated apoptosis, and ability to sustain telomere crisis by activating telomere reverse transcriptase.

Mitochondria: The anti-cancer target for the third millennium is a collection of up-to-date contributions investigating the role of these organelles in human pathology, in particular cancer.

Written by experts in the area of mitochondrial research, this book covers topics ranging from the basic science of the role of mitochondria in cellular homeostasis to more focused topics on the.

Cells with fewer mitochondria, on the other hand, are more sensitive to apoptotic signals, and this could make them less resistant to treatment. This could have a far-reaching impact in cancer treatment, since scientists could potentially use a combination of drugs to lower the number of mitochondria in cancer cells to induce cell suicide.

Mitochondria and Cancer. The mitochondria are ancient bacterial symbionts with their own mitochondrial DNA (mtDNA), RNA, and protein synthesizing systems. Each human cell contains hundreds of mitochondria. Margulis theorized that mitochondria are probably descended from free-living bacteria that survived endocytosis by a eukaryotic host cell.

This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited.

It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in.

An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C.

Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer. The mitochondrion (/ ˌ m aɪ t ə ˈ k ɒ n d r ɪ ə n /, plural mitochondria) is a semi autonomous double-membrane-bound organelle found in most eukaryotic organisms.

Some cells in some multicellular organisms may, however, lack mitochondria (for example, mature mammalian red blood cells).A number of unicellular organisms, such as microsporidia, parabasalids, and diplomonads, have also.

The NCI Dictionary of Cancer Terms features 8, terms related to cancer and medicine. We offer a widget that you can add to your website to let users look up cancer-related terms. Get NCI’s Dictionary of Cancer Terms Widget.

Since cancer mitochondria are vastly altered, specific targeting of dysfunctional processes and pathways may lead to novel treatment regiments (labeled in red). In cancer cells, manipulation of Bcl-2 antiapoptotic proteins can be used to induce apoptosis.

Lung mitochondria preferentially use glucose-derived substrates, such as pyruvate, for oxidative energy production; however, other energy sources, including FAs, Krebs cycle intermediates, glycerolphosphate, and glutamate, are also used, with the highest O 2 consumption rates achieved with succinate as a substrate ().Lung mitochondria also have a unique advantageous metabolic adaptation .The role of mitochondria in cancer extends well beyond their classical role of making the bioenergetic currency ATP.

Mitochondria are also the primary source of the basic building blocks from which lipids, nucleotides, and proteins are derived. 1 Recent insights reveal that mitochondria can regulate cell signaling and gene expression by tuning.Mitochondrial diseases are a group of disorders caused by dysfunctional mitochondria, the organelles that generate energy for the cell.

Mitochondria are found in every cell of the human body except red blood cells, and convert the energy of food molecules into the ATP that powers most cell functions. Mitochondrial diseases take on unique characteristics both because of the way the diseases Specialty: Medical genetics.

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